Antiplatelets

• A) COX Inhibitors
  • Aspirin
• B) PDE Inhibitors
  • Cyclic AMP Interference
  • Dipyridamol (Persantine)
• C) PARI
  • Thrombin Receptor Interference
  • Vorapaxar (Zontivity)
• D) P2Y12
  • ADP Binding Inhibitors
  • Clopidogrel (Plavix)
    • Thienopyridine (IR)
  • Prasugrel (Effient)
    • Thienopyridine (IR)
  • Ticagrelor (Brilinta)
    • Nucleotide/side analog (R)
    • SE: Dyspnea MC
  • Ticlopidine (Ticlid)
    • Thienopyridine (IR)
• E) GIIb/IIIa Receptor Inhibitors
  • Eptifibutide (Integrilin)
  • Abciximab (Repro)
    • Monoclonal antibody
  • Tirofiban (Aggrastat)
• F) PDE3 Inhibitors
  • Cilostazole (Pletal)
    • Only indicated in symptomatic claudication
    • CI: HF
• Reye Syndrome
  • Use of aspirin after a URI
  • Symptoms
    • Acute encephalopathy w/hepatic dysfunction occurring days after recovery
    • Heavy vomiting, delirium, fatty liver, seizures, coma
  • Liver failure with elevated AST, ALT
  • Increased PT, elevated ammonia, and hypoglycemia
  • +/- Renal and heart failure, Increased ICP