General

Categories:

UDS      
Drug Duration (+) – Short term Duration (+) – Long term False Positives
Amphetamine ≤2 days ≤4 days Atenolol, Propranolol, Bupropion, Nasal Decongestant
Cocaine ≤2 days ≤7 days High Specificity
Cannabis ≤3 days 1-2 months Hemp-containing foods
Opioids ≤3 days ≤3 days Poppy Seeds
Phencyclidine ≤7 days ≤7 days Dextromethorphan, Diphenhydramine, doxylamine, Ketamine, Tramadol, Venlafaxine
  • Measures morphine (Breakdown product of all-natural opioids)
    • Morphine, heroin, codeine
  • Can’t detect Semisynthetic and synthetic opioids
    • Oxycodone, hydrocodone, hydromorphone, fentanyl, meperidine, methadone, tramadol
    • Synthetic cannabinoids
    • Use Gas/Mass spectrometry
  • Drug Inducers/Inhibitors/Metabolism
    • Carbamazepine enhances Carbamazepine, Clonazepam, Itrazonazole metabolism
    • Phenytoin enhances Cortisol, Dexamethasone, Itraconazole metabolism
    • Spironolactone inhibits Digoxin metabolism
    • Cimetidine inhibits Diazepam, warfarin metabolism
  • Hepatic Blood flow limited
    • Amitriptyline, Isoniazid, Labetalol, Meperidine, Morphine, Propranolol, Verapamil
  • CYP Drugs
CYP Substrates Inducers Inhibitors
1A2 Acetaminophen, Duloxetine, Mirtazapine, Olanzapine, Ramelteon, Ropinirole, Tamoxifen, Tizanidine, Warfarin Green Vegetables, Grilled meat, Omeprazole, Smoking Cimetidine, Ciprofloxacin, Zileuton
2A6      
2B6 Bupropion, Clopidogrel, Cyclophosphamide, Ketamine, Methadone, Promethazine, Propofol, Selegiline, Sertraline, Ticlopidine Carbamazepine, Cyclophosphamide, Fosphenytoin, Phenobarbital, Rifampin Amiodarone, amlodipine, clopidogrel, fluoxetine, ketoconazole, paroxetine, sertraline
2C8 Amiodarone, Carbamazepine, Diclofenac, Ibuprofen Barbiturates Gemfibrozil, Montelukast, Trimethoprim
2C9 Celecoxib, Diclofenac, Dronabinol, Glimepiride, Glipizide, Glyburide, Ibuprofen, Losartan, Meloxicam, Naproxen, Phenobarbital, Phenytoin, Rosuvastatin, Sulfamethoxazole, Torsemide, Valsartan Barbiturates, Carbamazepine, Phenytoin, Rifampin Amiodarone, Clopidogrel, Fluconazole, Fluvoxamine, Metronidazole, Phenytoin, Sulfamethoxazole, Valproic Acid
2C18 Tolbutamide, Phenytoin Phenobarbital  
2C19 Aripiprazole, Citalopram, Clopidogreal, Diphenhydramine Barbiturates, Carbamazepine, Phenytoin Cimetidine
2D6 Amitriptyline, Carvedilol, Chlorpromazine, Clozapine, Fluoxetine, Haloperidol, Hydrocodone, Metoclopramide, Metoprolol, Nortriptyline, Oxycodone, Paroxetine, Risperidone, Selegiline, Tamoxifen, TCAs, Tramadol, Trazodone, Venlafaxine    
Bupropion, Diphenhydramine, Fluoxetine, Haloperidol, Paroxetine, Terbinafine      
2E1 Acetaminophen Ethanol Amitriptyline, Cimetidine, Modafinil, Selegiline, Sildenafil
3A4 Acetaminophen, Barbiturates, Carbamazepine, Glucocorticoids, Phenytoin Diltiazem, Verapamil

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