Prostate
Categories:
- GnRH Agonists
- MOA: Binds to GnRH receptor, causes initial release of FSH/LH followed by suppresion
- Leuprolide, Goserelin, Triptorelin, Buserelin, Histrelin
- Need anti-androgen too, at least for 1st 7 days, may make it worse
- GnRH Antagonists
- MOA: Binds to GnRH receptor and suppresses activity without initial increase in activit seen with GnRH agonists
- Degarelix, Relugolix
- Antiandrogen
- Bicalutamide
- Flutamide
- CYP17 Inhibitors
- Abiraterone + Prednisone
- Androgen Receptor Blockade
- Enzalutamide
- Apalutamide
- Tumor Vaccine
- Sipuleucel-T
- Chemotherapeutic
- MOA: Anti-microtubule agent
- Docetaxel/Cabazitaxel + Prednisone